abstract：:A circadian rhythm of serum concentrations of two tumor markers (CEA and AFP) was demonstrated in individuals not suffering from cancer. These rhythms exhibited a diurnal peak with a nocturnal dip. They disappeared in cancer groups. However, in some cancer subjects, a circadian activity was still detectable, but with ...

journal_title：Anticancer research

authors： Focan C,Focan-Henrard D,Collette J,Mechkouri M,Levi F,Hrushesky W,Touitou Y,Franchimont P

更新日期：1986-09-01 00:00:00

abstract：:Methods for improving the estrogen receptor (ER) and progestin receptor (PgR) assay were studied. Using DCC procedure as the basis, the extraction and incubation of ER and PgR is more efficiently achieved by phosphate buffer as compared with water, tris and veronal buffers. The multiple extractions of hormone receptor...

journal_title：Anticancer research

authors： Chen YM,Rice RG,Vaughn CB

更新日期：1986-07-01 00:00:00

abstract：:Urine and serum samples from a group of 359 individuals were studied in order to evaluate the usefulness of TPA in patients with urological cancers. Serum was taken from 110 people at 12 noon (S1), 5 pm (S2), and 8 am the following day (S3), while urine samples were collected from 73 individuals over three time interv...

journal_title：Anticancer research

authors： Costello CB,Kumar S

更新日期：1986-07-01 00:00:00

abstract：:The LAI reactivity of a colon organ specific neoantigen (OSN) was recovered from the urine of advanced colon cancer patients. In this study three physico-chemical steps were employed; precipitation by 80% ammonium sulfate, ion exchange, and molecular sieve chromatography. Each isolate was tested for activity and speci...

journal_title：Anticancer research

authors： Fink A,Harpaz N,Weisman Z,Shani A,Bentwich Z

更新日期：1986-07-01 00:00:00

abstract：:Rauscher erythroleukemia virus of the mouse was originally isolated from an animal bearing a lymphocytic neoplasm. In order to control extraneous influences on leukemia development, we modulated thymus-dependent and bursa-dependent lymphatic tissues and the granulopoietic and erythropoietic components of hemoreticular...

journal_title：Anticancer research

authors： Henkel B,Krueger GR

更新日期：1986-07-01 00:00:00

abstract：:Seventy five patients suffering from metastatic breast cancer previously unexposed to chemotherapy were treated with Cyclophosphamide, Methotrexate and 5-fluorouracil (CMF) upon diagnosis of their first relapse. Dose Level I (85% or more of the planned dose) was given to 14 patients (19%); Dose Level II (66% to 84% of...

journal_title：Anticancer research

authors： Brufman G,Biran S

更新日期：1986-07-01 00:00:00

abstract：:Primary cultures from 30 human gliomas (26 high grade, 3 low grade, and one oligoastrocytoma) were studied to examine the mixture of cells that make up the outgrowth, and their interactions. GFAP + ve Fibronectin - ve cells had a predominantly process forming (PF) morphology and formed complex networks around explants...

journal_title：Anticancer research

authors： Franks AJ,Burrow HM

更新日期：1986-07-01 00:00:00

abstract：:The events during the settlement of BSp73AS (AS) tumor cells in the syngeneic rat lung are described. Although AS cells show highly invasive behavior in vitro, subcutaneous primary tumors grow solidly without detectable metastatic spreading. However, AS cells when applied to the syngeneic rats via the tail vein give r...

journal_title：Anticancer research

authors： Knierim M,Paku S,Paweletz N,Spiess E

更新日期：1986-07-01 00:00:00

abstract：:The tumor progression concept was first defined by Foulds at the end of the nineteen fifties. His work about the evolution of mammary tumors led to the conclusion that a tumor is initiated as soon as a cell interacts with an oncogenic agent and that the tumor progresses by acquiring in a permanent and irreversible way...

journal_title：Anticancer research

authors： Lemieux L

更新日期：1986-05-01 00:00:00

abstract：:Around 1970 it was assumed that tumour cells are due to a single specific oncogenic mutation. This implied that daily many thousands of tumour cells would arise de novo and that most of these tumour cells were killed by immune surveillance or natural resistance mechanisms. Recent findings on immune surveillance and na...

journal_title：Anticancer research

authors： Den Otter W,Koten JW,Derkinderen DJ

更新日期：1986-05-01 00:00:00

abstract：:The effect of 4,6-benzylidene-D-glucose (BG) on chemically induced primary hepatocellular carcinomas in rats was tested after daily single injections of 85 mg per kg body weight into the aorta through a canula implanted through the right carotid artery. Treatment started immediately following a biopsy confirming the d...

journal_title：Anticancer research

authors： Pettersen EO,Schwarze PE,Dornish JM,Nesland JM

更新日期：1986-03-01 00:00:00

abstract：:Recent results concerning new antitumor metallocene derivatives have shown that not only numerous titanocene dihalides and bis(pseudohalides) exhibit antiproliferative activity, but that also some titanocene complexes (C5H5)2TiX2 containing carboxylates or hydrochlorinated aminothiophenolates as ligands X, are charact...

journal_title：Anticancer research

authors： Köpf-Maier P,Köpf H

更新日期：1986-03-01 00:00:00

abstract：:The centrifugal spreading of multicellular aggregates from a DMH induced colon adenocarcinoma cell line from rats was observed in vitro. Various concentrations of pentagastrin were added to the culture medium. Controls included medium alone or culture medium containing different concentrations of either NH4OH or NaOH ...

journal_title：Anticancer research

authors： Schallier D,Van der Elst J,De Neve W,Storme G

更新日期：1986-03-01 00:00:00

abstract：:Berlin-Druckrey (BD-IV) rats were used to evaluate the level of neoplastic transformation, initiation of DNA damage and repair following treatment with N-ethyl-N-nitrosourea (ENU). ENU, a potent neurocarcinogen in the Sprague-Dawley (CD) and BDIX rat strains, was a less potent neurocarcinogen when administered to 30 d...

journal_title：Anticancer research

authors： D'Ambrosio SM,Su C,Chang MJ,Oravec C,Stoica G,Koestner A

更新日期：1986-01-01 00:00:00

abstract：:The experimental techniques, methods of evaluation, and environmental implications of the findings of chemical carcinogenesis studies and related subject areas are herein critically reviewed. It is concluded that firstly, certain presently used procedures provide the best possibilities for the study of the hazardous n...

journal_title：Anticancer research

authors： Toth B

更新日期：1985-09-01 00:00:00

abstract：:Methodological aspects of testing chemosensitivity by the 6-day subrenal capsule (SRC) assay in immunocompetent mice were investigated. Human tumor xenografts, serially transplanted in athymic nude mice, were used as source of material. All drugs were given by the intravenous route. Administration of the drugs on days...

journal_title：Anticancer research

authors： Aamdal S,Fodstad O,Pihl A

更新日期：1985-07-01 00:00:00

abstract：:Three monoclonal antiidiotypic antibodies (AIA) to MOPC 315 IgA, G3 (IgG2b), A2 (IgG1) and D10 (a hybrid molecule consisting of gamma 1 and gamma 2a heavy chains), were characterized with respect to their binding constants (Ka) to MOPC 315 mouse myeloma cells. The Ka of G3 and A2 was 10(8)/mole; and that of D10 was 3 ...

journal_title：Anticancer research

authors： Marks A,Baumal R,Lei M,Ahmad A,Liu E

更新日期：1985-07-01 00:00:00

abstract：:Intratumoral (cervix uterine tumors) distribution of platinum was studied in ten patients after IV administration of CDDP. Sequential tumoral measurement of platinum was carried out 4, 24, and 48 h after the IV infusion. Platinum concentration in the tumor samples ranged from 0 to 29,5 ng/mg tissue. For all patients, ...

journal_title：Anticancer research

authors： Vennin P,Hecquet B,Fournier C,Demaille MC,Adenis L

更新日期：1985-07-01 00:00:00

abstract：:The cytosol hormone receptors were extracted from rabbit uteri and human tumors with tris buffer systems for three consecutive homogenization and centrifugation processes to obtain three cytosols C-1, C-2, and C-3. The assay results evaluated revealed that minimal to tremendous amounts of receptor activities were pres...

journal_title：Anticancer research

authors： Chen YM,Rice RG,Vaughn CB

更新日期：1985-07-01 00:00:00

abstract：:Yoshida tumors implanted subcutaneously in the rat are conspicuously heterogeneous. A definite zoning can be discerned. Cell nuclei range from uniform epitheloid (type I) via pleomorphic (type II) to compact (type III). Type III is seen to detach at the rim of the tumor and to infiltrate the dermis. Type I is characte...

journal_title：Anticancer research

authors： Jiwa M,Van den Hooff A

更新日期：1985-05-01 00:00:00

abstract：:Flunarizine, a calcium-antagonist drug that binds to calmodulin, was found to inhibit the migration of both B16 melanoma cells and M5076 macrophage-like cancer cells. The migration movement, both under agarose and through a polycarbonate filter membrane, was impaired by the drug. In M5076 macrophage-like cells Fc-depe...

journal_title：Anticancer research

authors： Sezzi ML,De Luca G,Materazzi M,Bellelli L

更新日期：1985-05-01 00:00:00

abstract：:We have previously shown biopsies from human malignant melanoma, as well as a cell line (MELUR) derived from human malignant melanoma cells, to contain dexamethasone (DEX) - and medroxyprogesterone acetate (MPA) - binding macromolecules exhibiting properties of glucocorticoid receptors from well-known target organs. I...

journal_title：Anticancer research

authors： Bojar H,Fabry W

更新日期：1985-03-01 00:00:00

abstract：:The significance of time interval for administration of a second drug after a first dose of cyclophosphamide (CTX) was studied for a human ovarian, lung, and colon carcinoma line growing as xenografts in nude mice. The effects of combination of two drugs were found to be dependent on the interval between the administr...

journal_title：Anticancer research

authors： Mattern J,Wauss K,Volm M

更新日期：1985-03-01 00:00:00

abstract：:A large number of different papillomavirus types have been identified. Several viruses often infect the same species and each virus is associated with a defined tissue. Recent evidence has shown that certain benign lesions can undergo malignant transformation in both animals and humans in response to genetic or enviro...

journal_title：Anticancer research

authors： Smith KT,Campo MS

更新日期：1985-01-01 00:00:00

abstract：:The distribution of receptors for estradiol (ER), progesterone (PgR) and androgens (DHTR) in 104 primary and 49 metastatic breast tumours from Indian women is herein being reported for the first time. When compared to reports in the literature, a lower percentage (47%) of ER (+) tumours and a higher percentage (49%) o...

journal_title：Anticancer research

authors： Seshadri R,Shah PN

更新日期：1984-11-01 00:00:00

abstract：:Human urothelial cell lines of non-malignant and malignant origin were classified into three grades of transformation, i.e. TGr I, TGr II, and TGr III, which differ from primary and early cultures of normal bladder mucosa (TGr 0) by growth in the absence of fibroblasts, prolonged survival, increasing chromosomal abnor...

journal_title：Anticancer research

authors： Christensen B,Kieler J,Vilien M,Don P,Wang CY,Wolf H

更新日期：1984-11-01 00:00:00

abstract：:Between 1975 and 1982, 202 previously untreated patients with multiple myeloma (MM) and clinical evidence of disease progression received intensive chemotherapy every 3-5 weeks to induce remission. Treatment regimen included intermittent courses of a combination of cycle non-specific drugs (melphalan, cyclophosphamide...

journal_title：Anticancer research

authors： Bataille R,Souteyrand P,Sany J

更新日期：1984-11-01 00:00:00

abstract：:Five functionalized benz(c)acridines - 5,6-dimethylbenz(c)acridine; 5,6,7-trimethylbenz(c)acridine; 7-chloro-5,6-dimethylbenz(c)acridine; 7-amino-5,6-dimethylbenz(c)acridine; 7-oxo-5,6-dimethylbenz(c)-acridine and 5,6-dimethylbenz(a)phenazine - were tested for mutagenic activity in the Ames Salmonella typhimurium assa...

journal_title：Anticancer research

authors： Walker BA,Rogan EG,Cromwell NH

更新日期：1984-11-01 00:00:00

abstract：:An adenovirus type 2-transformed rat embryo brain cell line (F 17 A2AS) and two of its subclones (F 17 CI, F 17 C2) have been studied using chromosome banding and flow cytometric techniques. In determining the modal chromosome number, a bimodal distribution was observed in each of the cell lines. In each case the firs...

journal_title：Anticancer research

authors： Arden KC,Pathak S,Swartzendruber DE,Zimmer SG

更新日期：1984-11-01 00:00:00

abstract：:The NB rat prostate adenocarcinoma model is one in which microscopic carcinoma can be induced via the use of testosterone and estrogen silastic implants. There is an incidence of large, grossly-positive tumors; which approaches 10% to 15%. Seventy-three percent of the animals subjected to this induction method for per...

journal_title：Anticancer research

authors： Drago JR

更新日期：1984-07-01 00:00:00

abstract：:The intratumor and intramuscle distribution of blood flow and plasma volume was studied via isotope techniques in a transplantable rat fibrosarcoma. Administration of two prostaglandin synthesis inhibitors, indomethacin and diclofenac-sodium, had different effects. Indomethacin changed muscle plasma volume significant...

journal_title：Anticancer research

authors： Karlsson L,Alpsten M,Peterson HI

更新日期：1984-05-01 00:00:00

abstract：:In long term culture of N-ethyl-N-nitrosourea (ENU) exposed fetal BD IX-rat brains, cells proliferate and form aggregates (nodules) in vitro, starting 2-3 months after the transplacental carcinogen injection in vivo. Cell nodules of cultures from 3-6 months after ENU exposure were investigated for the presence of orga...

journal_title：Anticancer research

authors： Mørk SJ

更新日期：1984-05-01 00:00:00

abstract：:Simultaneous administration of medroxyprogesterone acetate (MPA) and tamoxifen markedly elevated the serum alanine and aspartate aminotransferase activities in 4 out of 30 patients with endometrial or ovarian carcinoma; and also slightly increased the activities of gamma-glutamyl transferase in 2 of the patients. Thes...

journal_title：Anticancer research

authors： Riippa P,Kauppila A,Sundström H,Vihko R

更新日期：1984-05-01 00:00:00

abstract：:Receptors for peanut agglutinin (PNA) were isolated from Lewis lung carcinoma cells (3LL) by detergent solubilization and affinity chromatography on PNA-agarose. The isolated receptors showed heterogeneous yet distinct molecular species when they were analyzed by SDS gel electrophoresis. In vivo inoculation of the iso...

journal_title：Anticancer research

authors： Adachi M,Mizuta T,Yokota M,Shibusawa H,Yamamura M,Hamada Y,Uetsuji S,Yamamoto M,Miwa H

更新日期：1984-01-01 00:00:00

abstract：:A human metastatic meningiosarcoma has been established as a cell line as follows: At autopsy performed 12 hours after death, tumour nodules from the left parietal pleura were obtained under sterile conditions, minced and inoculated into culture vessels. The cells obtained were cloned, and clones with abnormal chromos...

journal_title：Anticancer research

authors： Korsgaard R,Clausen OP,Thorud E

更新日期：1984-01-01 00:00:00

abstract：:Binding of 20-[3H]-phorbol 2, 13-dibutyrate [( 3H] PDB) to intact human K 562 cells was characterized. Specific binding of [3H] PDB to K 562 cells at 20 degrees C or 37 degrees C reached a maximum within 15-20 min. Maximal specific [3H] PDB binding to K 562 cells was followed by a decline (down regulation) of radioact...

journal_title：Anticancer research

authors： Louache F,Villeval JL,Pelicci PG,Rouis M,Titeux M,Henri A,Rochant H,Thomopoulos P,Testa U

更新日期：1984-01-01 00:00:00

abstract：:The plasminogen activator (PA) activity and oestrogen and progestin receptor concentrations were determined in normal, benign and malignant tissues of human breast and ovary. The geometric mean of PA activity was significantly higher (p less than 0.05) in malignant than in normal breast tissue specimens. PA activity w...

journal_title：Anticancer research

authors： Isotalo H,Tryggvason K,Vierikko P,Kauppila A,Vihko R

更新日期：1983-09-01 00:00:00

abstract：:Hormone-dependent (HD) mammary tumors can be induced in mice and rats either by endocrine manipulations or by treatment with carcinogens. The tumors metastasize at a low frequency which may be due to immunogenic properties and does not exclude that the tumors are malignant. Hormone deprival may lead to tumor regressio...

journal_title：Anticancer research

authors： Briand P

更新日期：1983-07-01 00:00:00

abstract：:Keratinocytes originating from adult human hair follicles, the most convenient biopsy tissue, can be serially cultured using a combination of two techniques. Primary cultures are established using plucked scalp hair follicles and the bovine eye lens capsule as a growth substrate. Subsequently, cells from these culture...

journal_title：Anticancer research

authors： Weterings PJ,Roelofs HM,Jansen BA,Vermorken AJ

更新日期：1983-05-01 00:00:00

abstract：:The influence of psychoactive and nonpsychoactive cannabinoids on macromolecular biosynthesis and cell proliferation was compared in normal and transformed human cells which differ with respect to their abilities to metabolize polycyclic hydrocarbon-containing carcinogens. delta 9-THC, delta 8-THC, 11-OH-delta 9-THC, ...

journal_title：Anticancer research

authors： Green LG,Stein JL,Stein GS

更新日期：1983-05-01 00:00:00